molecular glue — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9849	HQ461		CDK , Molecular Glues
	HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.		CDK , Molecular Glues
T18391	N-Boc-4-pentyne-1-amine		Others , PROTAC Linker
	N-Boc-4-pentyne-1-amine is an alkyl chain-based PROTAC linker compound utilized in the synthesis of PROTAC MG-277[1].		Others , PROTAC Linker
T10703	Mezigdomide	CC-92480	Apoptosis , E1/E2/E3 Enzyme , Molecular Glues
	Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that often acts as a molecular glue. Mezigdomide has antimyeloma activity.		Apoptosis , E1/E2/E3 Enzyme , Molecular Glues
T60031	NRX-1933
	NRX-1933 is a molecular glue and enhances the interaction between an oncogenic transcription factor, β-Catenin, and its cognate E3 ligase, SCFβ-TrCP.
T60608	FPFT-2216		Casein Kinase , PDE , Molecular Glues
	FPFT-2216 is a "molecular glue" compound that degrades IKZF6, IKZF1, DE1D, and CK3α. FPFT-2216 has potential antitumor activity and can be used to study immune system diseases.		Casein Kinase , PDE , Molecular Glues
T12617	(R)-CR8 trihydrochloride	CR8, (R)-Isomer trihydrochloride	Apoptosis , CDK
	(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1/2/5/7/9 inhibitor that acts as a molecular glue degrader with neuroprotective activity and induces apoptosis.		Apoptosis , CDK
T40342	MC-VC-PABC-amide-PEG1-CH2-CC-885	MC-VC-PABC-amide-PEG1-CH2-CC-885
	MC-VC-PABC-amide-PEG1-CH2-CC-885 is an Antibody-Drug Conjugate (ADC) utilizing a protein-degrading agent (protac molecular glue, etc.).
T12027	MG-277		Mdm2
	MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.		Mdm2
T79138	Antitumor agent-100 hydrochloride		Molecular Glues
	Antitumor agent-100 hydrochloride (compound A6), serving as both an apoptosis inducer and molecular glue, exhibits superior anti-tumor activity [1].		Molecular Glues
T75139	TMX1
	TMX1 is a molecular glue degrader that covalently targets BRD4. It selectively recruits DCAF16 to the BRD4 BD2 domain, leading to the degradation of BRD4 [1].
T81705	Naphthyridine carbamate dimer	NCD	Molecular Glues
	Naphthyridine carbamate dimer (NCD) acts as a molecular glue for DNA, facilitating specific structural alterations within targeted functional DNA sequences to modulate their activity [1].		Molecular Glues
T79139	GBD-9		PROTACs
	GBD-9, a dual-mechanism degrader, effectively promotes the degradation of BTK and GSPT1 through recruitment of E3 ligase cereblon (CRBN). As a PROTAC molecule, GBD-9 induces BTK degradation, while also acting as a molecu...		PROTACs
T81781	MMH1
	MMH1, a novel molecular glue degrader of BRD4, operates by enlisting the CUL4 and DCAF16 ligases to target the second bromodomain (BRD4 BD2) [1].
T18061	KB02-SLF		Others
	KB02-SLF is a PROTAC-based nuclear FKBP12 degrader, known as a molecular glue. It facilitates the degradation of nuclear FKBP12 by covalently modifying DCAF16, an E3 ligase. Moreover, KB02-SLF enhances the longevity of p...		Others
T79736	14-3-3σ/ERα stabilizer-1		Estrogen Receptor/ERR
	Compound 181, also known as 14-3-3σ/ERα Stabilizer-1, is a covalent stabilizer targeting the 14-3-3σ/ERα proteins. It is utilized in research as a molecular glue [1].		Estrogen Receptor/ERR
T75112	LSN3160440
	LSN3160440 is an allosteric modulator of GLP-1R, functioning as a protein-protein interaction (PPI) stabilizer or molecular glue. It aids in the binding of inactive GLP-1 (9-36) NH2 to GLP-1R, enhancing receptor activati...
T81780	MMH2
	MMH2 is a novel molecular glue degrader targeting BRD4 by facilitating the recruitment of CUL4 and DCAF16 ligases to BRD4's second bromodomain (BRD4 BD2) [1].
T82177	HQ005
	HQ005, a potent CCNK degrader, exhibits an impressive DC50 value of 0.041 µM and functions as a molecular-glue degrader. By mediating interactions between target proteins and the ubiquitin-proteasome system, it facilitat...
T18060	KB02-JQ1		Others
	KB02-JQ1 is a potent and specific proteolysis targeting chimera (PROTAC) that specifically degrades BRD4, acting as a molecular glue. It does not degrade BRD2 or BRD3. The mechanism of action involves covalent modificati...		Others
T79870	RMC-4998		Ras
	RMC-4998 is a molecular glue compound exhibiting potent antitumor activity, capable of forming a ternary complex with CYPA and an activated KRAS G12C mutation. Binding of CYPA to KRAS G12C impedes the interaction between...		Ras